Can melatonin reduce the severity of COVID-19 pandemic?

A Shneider, A Kudriavtsev… - International reviews of …, 2020 - Taylor & Francis
The current COVID-19 pandemic is one of the most devastating events in recent history. The
virus causes relatively minor damage to young, healthy populations, imposing life …

Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality

DX Tan, RJ Reiter - Life Sciences, 2022 - Elsevier
The fear of SARS-CoV-2 infection is due to its high mortality related to seasonal flu. To date,
few medicines have been developed to significantly reduce the mortality of the severe …

COVID-19: Melatonin as a potential adjuvant treatment

R Zhang, X Wang, L Ni, X Di, B Ma, S Niu, C Liu… - Life sciences, 2020 - Elsevier
This article summarizes the likely benefits of melatonin in the attenuation of COVID-19
based on its putative pathogenesis. The recent outbreak of COVID-19 has become a …

[HTML][HTML] Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on …

DX Tan, R Hardeland - Melatonin Research, 2020 - melatonin-research.net
The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19,
and avian flu is often caused by the uncontrolled innate immune response and destructive …

[HTML][HTML] Therapeutic algorithm for use of melatonin in patients with COVID-19

RJ Reiter, P Abreu-Gonzalez, PE Marik… - Frontiers in …, 2020 - frontiersin.org
The coronavirus, COVID-19, has infected hundreds of thousands and killed tens of
thousands of individuals worldwide. This highly infectious condition continues to ravage the …

Clinical trial to test the efficacy of melatonin in COVID‐19

D Acuña‐Castroviejo, G Escames… - Journal of pineal …, 2020 - Wiley Online Library
The pharmacological properties of melatonin are well known. However, there is noticeable
the lack of clinical trials that confirm the efficacy, security, absence of side effects in the short …

Melatonin for the early treatment of COVID-19: a narrative review of current evidence and possible efficacy

KM Cross, DM Landis, L Sehgal, JD Payne - Endocrine Practice, 2021 - Elsevier
Objective To discuss the use of melatonin as an early treatment option on the first day of
diagnosis for COVID-19. Methods Medical Subject Headings terms “COVID-19” and “viral …

[HTML][HTML] Possible application of melatonin in long COVID

DP Cardinali, GM Brown, SR Pandi-Perumal - Biomolecules, 2022 - mdpi.com
Clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger
for months beyond the acute stage of SARS-CoV-2 infection,“long COVID”. Among the long …

[HTML][HTML] Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection

RJ Reiter, R Sharma, F Simko… - Cellular and Molecular …, 2022 - Springer
Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …

[HTML][HTML] Melatonin as a potential adjuvant treatment for COVID-19 beyond sleep disorders

A Wichniak, A Kania, M Siemiński… - International Journal of …, 2021 - mdpi.com
Melatonin is registered to treat circadian rhythm sleep–wake disorders and insomnia in
patients aged 55 years and over. The essential role of the circadian sleep rhythm in the …