Approximately half of all human genes have CpG islands (CGIs) around their promoter
regions. Although CGIs usually escape methylation, those on Chromosome X in females …

DNA methylation is a covalent modification of the nucleotide cytosine that is stably inherited
at the dinucleotide CpG by somatic cells, and 70% of CpG dinucleotides in the genome are …

The human genome contains∼ 30,000 CpG islands (CGIs). While CGIs associated with
promoters nearly always remain unmethylated, many of the∼ 9,000 CGIs lying within gene …

CpG islands (CGIs) are commonly used as genomic markers to study the patterns and
regulatory consequences of DNA methylation. Interestingly, recent studies reveal a …

Mammalian genomes are punctuated by DNA sequences containing an atypically high
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation …

The role of CpG island methylation in normal development and cell differentiation is of keen
interest, but remains poorly understood. We performed comprehensive DNA methylation …

CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient
human genome and associate with many gene promoters. As CGIs also differ from bulk …

CpG island methylation plays an important role in epigenetic gene control during
mammalian development and is frequently altered in disease situations such as cancer. The …

CpG islands (CGIs) are one of the most widely studied regulatory features of the human
genome, with critical roles in development and disease. Despite such significance and the …

Human and mouse genomes contain a similar number of CpG islands (CGIs), which are
discrete CpG-rich DNA sequences associated with transcription start sites. In both …