Polycystic kidney disease (PKD) is a diverse group of human monogenic lethal conditions
inherited as autosomal dominant (AD) or recessive (AR) traits. Recent development of …

Numerous murine (mouse and rat) models of polycystic kidney disease (PKD) have been
described in which the mutant phenotype results from a spontaneous mutation or …

Polycystic kidney disease (PKD) is a developmental kidney disorder which can be inherited
as either an autosomal dominant trait, with an incidence of 1: 50 to 1: 1000, or as an …

An increased understanding of the genetic, molecular and cellular mechanisms responsible
for the development of polycystic kidney disease has laid out the foundation for the …

Autosomal dominant polycystic kidney disease (ADPKD) is one of the commonest inherited
human disorders yet remains relatively unknown to the wider medical, scientific and public …

Polycystic kidney disease (PKD) is a disease of the nephron, characterized by the formation
of multiple renal tubular cysts, leading to endstage renal failure. The most common form is …

Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive
polycystic kidney disease (ARPKD) are significant causes of morbidity and mortality in …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or
PKD2, which encode polycystin-1 and polycystin-2, respectively. Rodent models are …

New insights into the molecular pathophysiology of polycystic kidney disease. Polycystic
kidney diseases are characterized by the progressive expansion of multiple cystic lesions …

Polycystic kidney disease (PKD), a common genetic cause of chronic renal failure in
children and adults, is characterized by the accumulation of fluid-filled cysts in the kidney …