Murine Pkd1 is a developmentally regulated gene from morula to adulthood: Role in tissue condensation and patterning
R Guillaume, V D'Agati, M Daoust… - … dynamics: an official …, 1999 - Wiley Online Library
PKD1 is the most common genetically mutated gene involved in autosomal dominant
polycystic kidney disease (ADPKD). Our previous studies have shown that the pathogenesis …
polycystic kidney disease (ADPKD). Our previous studies have shown that the pathogenesis …
Molecular basis of autosomal dominant polycystic kidney disease
L Al-Bhalal, M Akhtar - Advances in anatomic pathology, 2005 - journals.lww.com
Autosomal dominant polycystic kidney disease (ADPKD) is a serious, life-threatening
genetic disease in which extensive epithelial-lined cysts develop in the kidneys and, to a …
genetic disease in which extensive epithelial-lined cysts develop in the kidneys and, to a …
Novel targets for the treatment of autosomal dominant polycystic kidney disease
FA Belibi, CL Edelstein - Expert opinion on investigational drugs, 2010 - Taylor & Francis
Importance of the field: Autosomal dominant (AD) polycystic kidney disease (PKD) is the
most common life-threatening hereditary disorder. There is currently no therapy that slows or …
most common life-threatening hereditary disorder. There is currently no therapy that slows or …
Overexpression of PKD1 causes polycystic kidney disease
C Thivierge, A Kurbegovic, M Couillard… - … and cellular biology, 2006 - Am Soc Microbiol
The pathogenetic mechanisms underlying autosomal dominant polycystic kidney disease
(ADPKD) remain to be elucidated. While there is evidence that Pkd1 gene haploinsufficiency …
(ADPKD) remain to be elucidated. While there is evidence that Pkd1 gene haploinsufficiency …
Autosomal dominant polycystic kidney disease: clues to pathogenesis
PC Harris - Human molecular genetics, 1999 - academic.oup.com
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutation of one of two
genes: PKD1 (16p13. 3) or PKD2 (4q13–23). PKD1 accounts for∼ 85% of pedigrees and is …
genes: PKD1 (16p13. 3) or PKD2 (4q13–23). PKD1 accounts for∼ 85% of pedigrees and is …
Polycystic kidney disease
PC Harris, VE Torres - Annual review of medicine, 2009 - annualreviews.org
A number of inherited disorders result in renal cyst development. The most common form,
autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed …
autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed …
PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells
Mutations of the polycystic kidney and hepatic disease 1 (PKHD1) gene have been shown to
cause autosomal recessive polycystic kidney disease (ARPKD), but the cellular functions of …
cause autosomal recessive polycystic kidney disease (ARPKD), but the cellular functions of …
Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2
Autosomal dominant polycystic kidney disease (ADPKD) is caused by germ line mutations in
at least three ADPKD genes. Two recently isolated ADPKD genes, PKD1 and PKD2, encode …
at least three ADPKD genes. Two recently isolated ADPKD genes, PKD1 and PKD2, encode …
Polycystic kidney disease
J Ghata, BD Cowley Jr - Comprehensive Physiology, 2011 - Wiley Online Library
Renal cysts, which arise from renal tubules, can be seen in a variety of hereditary and
nonhereditary entities. Common mechanisms associated with renal cyst formation include …
nonhereditary entities. Common mechanisms associated with renal cyst formation include …