PKD is characterized by progressive cystic dilation of the renal tubules, which results in
nephromegaly and often culminates in end-stage renal disease. PKD can be inherited as …

Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease
(ADPKD) and autosomal recessive polycystic kidney d isease (ARPKD), is characterized by …

Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited
renal disease, characterized by multiple cysts that can eventually lead to kidney failure …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by cyst formation
in the kidney, liver, and pancreas and is associated often with cardiovascular abnormalities …

Recent studies have identified the genes mutated in the two major forms of autosomal
dominant polycystic kidney disease, PKD1 and PKD2. The PKD1 gene product is likely to be …

Autosomal recessive polycystic kidney disease (ARPKD) is a serious genetic disease
characterized by cystic changes in the collecting ducts of the kidney and bile ducts within the …

Background Autosomal recessive (AR) polycystic kidney disease (PKD) is characterized in
humans and mice as a rapidly progressive, collecting duct cystic disease usually leading to …

Autosomal Dominant Polycystic Kidney Disease (ADPKD; MIM ID's 173900, 601313,
613095) leads to end-stage kidney disease, caused by mutations in PKD1 or PKD2 …

Autosomal dominant polycystic kidney disease (ADPKD) is a major, inherited disorder that is
characterized by the growth of large, fluid-filled cysts from the tubules and collecting ducts of …

To elucidate the molecular pathways that modulate renal cyst growth in ADPKD, we
performed global gene profiling on cysts of different size (< 1 ml, n= 5; 10–20 ml, n= 5;> 50 …