DNA methylation in the developing hippocampus and amygdala of anxiety-prone versus risk-taking rats

RK Simmons, JL Howard, DN Simpson, H Akil… - Developmental …, 2012 - karger.com
All organisms exhibit a wide range of emotional behaviors and interact with the environment
in different ways. Some individuals may be more quiet and shy whereas others are more …

[PDF][PDF] DNA methylation within the amygdala early in life increases susceptibility for depression and anxiety disorders

I Vonderwalde - The Journal of Neuroscience, 2019 - Soc Neuroscience
The presentation and development of psychiatric illnesses is affected by interindividual
variability in brain morphology and genetics (Tost et al., 2012; Smoller, 2016). Epigenetic …

Altered DNA methylation in the developing brains of rats genetically prone to high versus low anxiety

CR McCoy, ME Glover, LT Flynn… - Journal of …, 2019 - Soc Neuroscience
There is growing evidence of abnormal epigenetic processes playing a role in the
neurobiology of psychiatric disorders, although the precise nature of these anomalies …

Global and gene-specific DNA methylation alterations in the adolescent amygdala and hippocampus in an animal model of caregiver maltreatment

TS Doherty, A Forster, TL Roth - Behavioural brain research, 2016 - Elsevier
Epigenetic mechanisms such as DNA methylation are part of an emerging story on how
early-life experiences can alter behavioral trajectories and lead to the development of …

Genetic predisposition to high anxiety-and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala

CR McCoy, NL Jackson, J Day, SM Clinton - Behavioural brain research, 2017 - Elsevier
Understanding biological mechanisms that shape vulnerability to emotional dysfunction is
critical for elucidating the neurobiology of psychiatric illnesses like anxiety and depression …

Differential methylation of genes in the medial prefrontal cortex of developing and adult rats following exposure to maltreatment or nurturing care during infancy

J Blaze, L Scheuing, TL Roth - Developmental neuroscience, 2013 - karger.com
Quality of maternal care in infancy is an important contributing factor in the development of
behavior and psychopathology. One way maternal care could affect behavioral trajectories …

[HTML][HTML] Methyl donor-deficient diet during development can affect fear and anxiety in adulthood in C57BL/6J mice

D Ishii, D Matsuzawa, S Matsuda, H Tomizawa… - PloS one, 2014 - journals.plos.org
DNA methylation is one of the essential factors in the control of gene expression. Folic acid,
methionine and choline (methyl donors)–all nutrients related to one-carbon metabolism–are …

DNA methylation markers in the postnatal developing rat brain

RK Simmons, SA Stringfellow, ME Glover, AA Wagle… - Brain research, 2013 - Elsevier
In spite of intense interest in how altered epigenetic processes including DNA methylation
may contribute to psychiatric and neurodevelopmental disorders, there is a limited …

Exposure to extrinsic stressors, social defeat or bisphenol A, eliminates sex differences in DNA methyltransferase expression in the amygdala

EC Wright, SA Johnson, R Hao… - Journal of …, 2017 - Wiley Online Library
Chemical and psychological stressors can exert long lasting changes in brain function and
behaviour. Changes in DNA methylation have been shown to be an important mechanism …

Inhibition of DNA methylation in the developing rat brain disrupts sexually dimorphic neurobehavioral phenotypes in adulthood

Y Li, Q Ma, C Dasgupta, S Halavi, RE Hartman… - Molecular …, 2017 - Springer
Accumulating evidence indicates a critical implication of DNA methylation in the brain
development. We aim to determine whether the disruption of DNA methylation patterns in …