DNA methylation is found almost ubiquitously in nature and the methyltransferases show
evidence of a common evolutionary origin. It will be a fascinating study in protein evolution …

In addition to the four bases incorporated into DNA during semiconservative replication
there is a variable number of other bases present in DNA in small amounts. These arise by …

Publisher Summary The chapter discusses on the DNA methylation and its possible
biological roles. The pattern of DNA methylation is species-specific. In the DNA of some …

Structure and Function of DNA Methyltransferases Page 1 Annu. Rev. Biophys. Biomol. Struct.
1995.24:293-318 Copyright © 1995 by Annual Reviews Inc. All rights reserved STRUCTURE …

DNA methylation and its functional significance, particularly in eukaryotic systems, have
become very active areas of research. Although the biochem istry of DNA methylation has …

The occurrence of 5-methylcytosine in DNA was first described in 1948 by Hotchkiss (see
first chapter). Recognition of its possible physiologi cal role in eucaryotes was first …

Understanding the mechanisms involved in the regulation of gene expression in eukaryotic
organisms is one of the major challenges facing the modern molecular biologist. Despite …

The haploid mammalian genome contains~ 5× 10 7 CpG dinucleotides (Schwartz et al.,
1962), about 60% of which are methylated at the 5 position of the cytosine residue (Bestor et …

The DNA of many organisms contains modified bases such as 5-methylcytosine and 6-
methyladenine, in addition to the four unmodified bases (reviewed by Razin and Szyf …

Publisher Summary Almost all biological macromolecules undergo some form of processing
event subsequent to their biosynthesis. These processes such as cleaving, phosphorylation …