MeCP2 is an abundant mammalian protein that binds methylated CpG (mCpG) sequences
within double-stranded DNA, represses transcription by recruiting histone deacetylases, and …

Methyl CpG binding protein 2 (MeCP2) is a basic protein that contains a DNA methyl binding
domain. The mechanism by which the highly positive charge of MeCP2 and its ability to bind …

The methyl-CpG binding domain (MBD) of the transcriptional repressor MeCP2 has been
proposed to recognize a single symmetrically methylated CpG base pair via hydrophobic …

Methylation ofcytosine residues in mammalian genomes is associated with transcriptional
repression and inactive chromatin. It has been shown that methylation of DNA is essential …

CpG methylation, the most common epigenetic modification of vertebrate genomes, is
primarily associated with transcriptional repression. MeCP2, MBD1, MBD2, MBD3 and …

The protein MeCP2 mediates epigenetic regulation by binding methyl-CpG (mCpG) sites on
chromatin. MeCP2 consists of six domains of which one, the methyl binding domain (MBD) …

DNA methylation plays an important role in mammalian development and correlates with
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …

Methylation of cytosine at CpG dinucleotides is a common feature of many higher eukaryotic
genomes. A major biological consequence of DNA methylation is gene silencing. Increasing …

MeCP2 is a chromosomal protein that is concentrated in the centromeric heterochromatin of
mouse cells. In vitro, the protein binds preferentially to DNA containing a single …

MeCP2 is an abundant mammalian protein that binds to methylated CpG. We have found
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …