Background In order to gain insight into the contribution of DNA methylation to disease
progression of chronic lymphocytic leukemia (CLL), using 450K Illumina arrays, we …

Deregulated transcriptional control caused by aberrant DNA methylation and/or histone
modifications is a hallmark of cancer cells. In chronic lymphocytic leukemia (CLL), the most …

Acquired resistance to chemotherapy is an important clinical problem and can also occur
without detectable cytogenetic aberrations or gene mutations. Chronic lymphocytic leukemia …

We performed a genome-wide analysis of aberrant DNA methylation in chronic lymphocytic
leukemia (CLL) using methylated CpG island amplification (MCA) coupled with a promoter …

Over the past two decades, aberrant DNA methylation has emerged as a key player in the
pathogenesis of chronic lymphocytic leukemia (CLL), and knowledge regarding its …

Chronic lymphocytic leukemia (CLL) is characterized by widespread alterations in the
genetic and epigenetic landscapes which seem to underlie the variable clinical …

Aims: B-cell chronic lymphocytic leukemia (CLL) is a heterogeneous malignancy that
clinically ranges from indolent to rapidly progressive. CLL, like other cancers, can be …

Epigenetic regulation has been thoroughly investigated in recent years and has emerged as
an important aspect of chronic lymphocytic leukemia (CLL) biology. Characteristic aberrant …

In chronic lymphocytic leukemia (CLL), the microenvironment influences gene expression
patterns; however, knowledge is limited regarding the extent to which methylation changes …

Cytosine derivative dysregulations represent important epigenetic modifications whose
impact on the clinical outcome in chronic lymphocytic leukemia (CLL) is incompletely …