Phytochemical antioxidants modulate mammalian cellular epigenome: implications in health and disease

S Malireddy, SR Kotha, JD Secor… - Antioxidants & redox …, 2012 - liebertpub.com
In living systems, the mechanisms of inheritance involving gene expression are operated by
(i) the traditional model of genetics where the deoxyribonucleic acid (DNA) transcription and …

Dietary antioxidants remodel DNA methylation patterns in chronic disease

M Beetch, S Harandi‐Zadeh, K Shen… - British journal of …, 2020 - Wiley Online Library
Chronic diseases account for over 60% of all deaths worldwide according to the World
Health Organization reports. Majority of cases are triggered by environmental exposures that …

The role of dietary phenolic compounds in epigenetic modulation involved in inflammatory processes

M Číž, A Dvořáková, V Skočková, L Kubala - Antioxidants, 2020 - mdpi.com
A better understanding of the interactions between dietary phenolic compounds and the
epigenetics of inflammation may impact pathological conditions and their treatment …

Health-promoting role of dietary bioactive compounds through epigenetic modulations: a novel prophylactic and therapeutic approach

A Kumari, S Bhawal, S Kapila, H Yadav… - Critical Reviews in …, 2022 - Taylor & Francis
The epigenome is an overall epigenetic state of an organism, which is as important as that of
the genome for normal development and functioning of an individual. Epigenetics involves …

Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges

E Shankar, R Kanwal, M Candamo, S Gupta - Seminars in cancer biology, 2016 - Elsevier
The influence of diet and environment on human health has been known since ages. Plant-
derived natural bioactive compounds (phytochemicals) have acquired an important role in …

Redox signaling, mitochondrial metabolism, epigenetics and redox active phytochemicals

R Wu, S Li, R Hudlikar, L Wang, A Shannar… - Free Radical Biology …, 2022 - Elsevier
Biological redox signaling plays an important role in many diseases. Redox signaling
involves reductive and oxidative mechanisms. Oxidative stress occurs when reductive …

Dietary phytochemicals and cancer chemoprevention: a perspective on oxidative stress, inflammation, and epigenetics

W Li, Y Guo, C Zhang, R Wu, AY Yang… - Chemical research in …, 2016 - ACS Publications
Oxidative stress occurs when cellular reactive oxygen species levels exceed the self-
antioxidant capacity of the body. Oxidative stress induces many pathological changes …

Nutriepigenomics in environmental-associated oxidative stress

K Rubio, EY Hernández-Cruz, DG Rogel-Ayala… - Antioxidants, 2023 - mdpi.com
Complex molecular mechanisms define our responses to environmental stimuli. Beyond the
DNA sequence itself, epigenetic machinery orchestrates changes in gene expression …

The redox basis of epigenetic modifications: from mechanisms to functional consequences

AR Cyr, FE Domann - Antioxidants & redox signaling, 2011 - liebertpub.com
Epigenetic modifications represent mechanisms by which cells may effectively translate
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …

A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics

ZY Su, L Shu, TO Khor, JH Lee, F Fuentes… - Natural products in …, 2013 - Springer
Oxidative stress is caused by an imbalance of reactive oxygen species (ROS)/reactive
nitrogen species (RNS) and the antioxidative stress defense systems in cells. ROS/RNS or …