TET2 is essential for survival and hematopoietic stem cell homeostasis
K Shide, T Kameda, H Shimoda, T Yamaji, H Abe… - Leukemia, 2012 - nature.com
Abstract Ten-Eleven-Translocation 2 (TET2) is an enzyme that catalyzes the conversion of 5-
methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state …
methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state …
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
M Ko, HS Bandukwala, J An… - Proceedings of the …, 2011 - National Acad Sciences
The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes
that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5 …
that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5 …
Ten‐Eleven‐Translocation 2 (TET 2) is downregulated in myelodysplastic syndromes
R Scopim‐Ribeiro, JA Machado‐Neto… - European Journal of …, 2015 - Wiley Online Library
TET2, a member of the ten‐eleven‐translocation (TET) family genes that modify DNA by
converting 5‐methylcytosine (5‐mC) to 5‐hydroxymethylcytosine (5‐hmC), is located in …
converting 5‐methylcytosine (5‐mC) to 5‐hydroxymethylcytosine (5‐hmC), is located in …
TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells
T Langlois, B da Costa Reis Monte-Mor, G Lenglet… - Stem Cells, 2014 - academic.oup.com
Abstract Ten-eleven-translocation 2 (TET2) belongs to the TET protein family that catalyzes
the conversion of 5-methylcytosine into 5-hydroxymethylcytosine and plays a central role in …
the conversion of 5-methylcytosine into 5-hydroxymethylcytosine and plays a central role in …
The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases
E Solary, OA Bernard, A Tefferi, F Fuks, W Vainchenker - Leukemia, 2014 - nature.com
Abstract Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation,
deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event …
deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event …
TET2 in normal and malignant hematopoiesis
RL Bowman, RL Levine - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
The ten-eleven translocation (TET) family of enzymes were originally cloned from the
translocation breakpoint of t (10; 11) in infant acute myeloid leukemia (AML) with …
translocation breakpoint of t (10; 11) in infant acute myeloid leukemia (AML) with …
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
K Moran-Crusio, L Reavie, A Shih, O Abdel-Wahab… - Cancer cell, 2011 - cell.com
Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a
significant proportion of patients with myeloid malignancies. Although there are extensive …
significant proportion of patients with myeloid malignancies. Although there are extensive …
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
Z Li, X Cai, CL Cai, J Wang, W Zhang… - Blood, The Journal …, 2011 - ashpublications.org
TET2 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies
including MDS, CMML, MPN, and AML. However, little is known regarding the biological …
including MDS, CMML, MPN, and AML. However, little is known regarding the biological …
Role of TET2 Mutations in Myeloproliferative Neoplasms
E Pronier, F Delhommeau - Current hematologic malignancy reports, 2012 - Springer
Abstract Recently, 5-hydroxymethylcytosine (5-hmC), the 6th base of DNA, was discovered
as the product of the hydroxylation of 5-methylcytosine (5-mC) by the ten-eleven …
as the product of the hydroxylation of 5-methylcytosine (5-mC) by the ten-eleven …
The TET2 interactors and their links to hematological malignancies
Ten‐eleven translocation (TET) family proteins are dioxygenases that oxidize 5‐
methylcytosine to 5‐hydroxymethylcytosine, 5‐formylcytosine, and 5‐carboxylcytosine in …
methylcytosine to 5‐hydroxymethylcytosine, 5‐formylcytosine, and 5‐carboxylcytosine in …