Associations between childhood maltreatment and DNA methylation of the oxytocin receptor gene in immune cells of mother–newborn dyads

L Ramo-Fernández, AM Gumpp, C Boeck… - Translational …, 2021 - nature.com
The neuropeptide oxytocin (OXT) and its receptor (OXTR) modulate interpersonal
relationships, particularly mother–child interactions. DNA methylation (DNAm) changes of …

Sex-dependent association between variability in infants' OXTR methylation at birth and negative affectivity at 3 months

S Nazzari, S Grumi, M Villa, F Mambretti… - …, 2022 - Elsevier
Background Sex-specific differences in DNA methylation of the oxytocin receptor gene
(OXTR) have been shown in adults and are related to several mental disorders. Negative …

The DNA methylation landscape of the human oxytocin receptor gene (OXTR): data-driven clusters and their relation to gene expression and childhood adversity

S Müller, M Sicorello, D Moser, L Frach… - Translational …, 2023 - nature.com
The oxytocin receptor gene (OXTR) is of interest when investigating the effects of early
adversity on DNA methylation. However, there is heterogeneity regarding the selection of …

A role of oxytocin receptor gene brain tissue expression quantitative trait locus rs237895 in the intergenerational transmission of the effects of maternal childhood …

P Toepfer, KJ O'Donnell, S Entringer, CM Heim… - Journal of the American …, 2019 - Elsevier
Objective Women exposed to childhood maltreatment (CM) are more likely to exhibit
insensitive parenting, which may have consequences for their offspring's development …

Child maltreatment is associated with a reduction of the oxytocin receptor in peripheral blood mononuclear cells

S Krause, C Boeck, AM Gumpp, E Rottler… - Frontiers in …, 2018 - frontiersin.org
Background: Child maltreatment (CM) and attachment experiences are closely linked to
alterations in the human oxytocin (OXT) system. However, human data about oxytocin …

Perinatal depression and DNA methylation of oxytocin-related genes: a study of mothers and their children

L King, S Robins, G Chen, V Yerko, Y Zhou… - Hormones and …, 2017 - Elsevier
The present study investigated the association of perinatal depression (PD) with differential
methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin …

Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness

P Toepfer, KJ O'Donnell, S Entringer, E Garg… - …, 2019 - Elsevier
Maternal behavior (MB) is observable across mammals and represents an important feature
of environmental variation during early postnatal development. Oxytocin (OT) plays a crucial …

[HTML][HTML] Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies

EJ Kraaijenvanger, Y He, H Spencer, AK Smith… - Neuroscience & …, 2019 - Elsevier
The human oxytocin (OXT) system is implicated in the regulation of complex social
behaviors, as well as in psychopathologies characterized by social deficits. Emerging …

Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress

I Milaniak, CAM Cecil, ED Barker, CL Relton… - Development and …, 2017 - cambridge.org
Emerging research in epigenetics has shown that there is variability in how environmental
exposures “get under the skin” through mechanisms like DNA methylation to influence gene …

The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review

C Maud, J Ryan, JE McIntosh, CA Olsson - BMC psychiatry, 2018 - Springer
Abstract Background The neuropeptide Oxytocin (OXT) plays a central role in birthing,
mother-infant bonding and a broad range of related social behaviours in mammals. More …