Background Despite well-documented effects on human health, the action modes of
environmental pollutants are incompletely understood. Although transcriptome-based …

Background Many common diseases arise from an interaction between environmental and
genetic factors. Our knowledge regarding environment and gene interactions is growing, but …

Chemicals are important environmental factors that can affect human health, yet the
molecular mechanisms connecting an exposure to an adverse outcome often remain …

Epigenome-wide mediation analysis aims to identify DNA methylation CpG sites that
mediate the causal effects of genetic/environmental exposures on health outcomes …

Through investigating the combined impact of the environmental exposures experienced by
an individual throughout their lifetime, exposome research provides opportunities to …

Environmental health studies relate how exposures (eg, chemicals) affect human health and
disease; however, in most cases, the molecular and biological mechanisms connecting an …

Understanding the complex interplay of genetic and environmental factors in disease
etiology and the role of gene-environment interactions (GEIs) across human development …

Background Exposure to air particulate matter is known to elevate blood biomarkers of
inflammation and to increase cardiopulmonary morbidity and mortality. Major components of …

Large national-level electronic health record (EHR) datasets offer new opportunities for
disentangling the role of genes and environment through deep phenotype information and …

Conventional environmental health studies have primarily focused on limited environmental
stressors at the population level, which lacks the power to dissect the complexity and …