Background DNA methylation plays an essential role in the regulation of gene expression.
While its presence near the transcription start site of a gene has been associated with …

Background Epigenetic polymorphisms are a potential source of human diversity, but their
frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an …

Genomic DNA methylation profiles exhibit substantial variation within the human population,
with important functional implications for gene regulation. So far little is known about the …

Background DNA methylation is an essential epigenetic mechanism involved in gene
regulation and disease, but little is known about the mechanisms underlying inter-individual …

Genomic DNA methylation contributes substantively to transcriptional regulations that
underlie mammalian development and cellular differentiation. Much effort has been made to …

DNA methylation patterns are important for establishing cell, tissue, and organism
phenotypes, but little is known about their contribution to natural human variation. To …

Background Ethnic differences in human DNA methylation have been shown for a number of
CpG sites, but the genome-wide patterns and extent of these differences are largely …

Differential DNA methylation is an essential epigenetic signal for gene regulation,
development, and disease processes. We mapped DNA methylation patterns of 190 gene …

The methylation of cytosines in CpG dinucleotides is essential for cellular differentiation and
the progression of many cancers, and it plays an important role in gametic imprinting. To …

DNA methylation has been viewed as a stable component of the epigenome, which is
established during development and fixed thereafter. We show here using nearest neighbor …