The rapid progress in deciphering the processes of covalent histone modifications has
broadened our understanding of transcriptional regulation. Histone lysine methylation, along …

Histone lysine methylation plays a fundamental role in chromatin organization and function.
This epigenetic mark is involved in many biological processes such as heterochromatin …

Covalent modifications of histone tails have fundamental roles in chromatin structure and
function. One such modification, lysine methylation, has important functions in many …

Histone lysine methylation is regarded as a very stable modification with important functions
in epigenetic gene control and for organizing chromatin domains. While more robust …

Diverse post-translational modifications of histone amino termini represent an important
epigenetic mechanism for the organisation of chromatin structure and the regulation of gene …

In eukaryotic organisms, the replication of the DNA sequence and its organization into
chromatin are critical to maintain genome integrity. Chromatin components, such as histone …

Epigenetic mechanisms control eukaryotic development beyond DNA‐stored information.
There are several pathways, including histone tail modifications, histone variant …

The N termini of nucleosomal histone polypeptides are both highly accessible and
extensively modified by various chemical moieties. Interpreting the language of these …

Histone methylation was first described more than 35 years ago, but its role has remained
enigmatic. Proposed functions range from transcriptional regulation to the higher-order …

Histone methylation is believed to play important roles in epigenetic memory in various
biological processes. However, questions like whether the methylation marks themselves …