This report identifies l‐ethionine as an inducer of differentiation in murine erythroleukemia
cells. When Friend erythroleukemia cells are grown in the presence of 4 mM l‐ethionine …

We have analyzed DNA modification in the human+/I-globin gene region at 17 cleavage
sites of restriction endonucleases which are unable to cleave DNA if 5-methylcytosine is …

In addition to the four bases incorporated into DNA during semiconservative replication
there is a variable number of other bases present in DNA in small amounts. These arise by …

Several lines of evidence strongly indicate that methylation of cytosine residues within CpG
dinucleotides are implicated in the regulation of gene expression in eukaryotes. Transfection …

During the past few decades we have witnessed an era of remarkable growth in the field of
molecular biology. In 1950 very little was known of the chemical constitution of biological …

Is DNA methylation a key element in the regulation of vertebrate gene expression, or does it
play a minor part? There is support for both views in the recent literature, for while it is now …

The effect of DNA methylation on the transcriptional activity of the hamster adenine
phosphoribosyltransferase (aprt) and the herpes thymidine kinase (tk) genes has been …

Ever since methylcytosine was found in genomic DNA, this epigenetic alteration has
become a center of scientific attraction, especially because of its relation to gene silencing in …

About 60% of CpG dinucleotides in vertebrate DNA are methylated at position 5 of the
cytosine base. DNA methylation is essential for mammalian development [11, but places a …