Publisher Summary This chapter discusses the deoxyribonucleic acid (DNA) methylation
from embryo to adult. The existence of tissue-specific methylation patterns and the results of …

Despite thousands of articles about 5-methylcytosine (m5C) residues in vertebrate DNA,
there is still controversy concerning the role of genomic m5C in normal vertebrate …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

The overall DNA methylation level sharply decreases from the zygote to the blastocyst stage
despite the presence of high levels of DNA methyltransferase (Dnmt1). Surprisingly, the …

Epigenetic modification of the cytosine base of DNA by its methylation introduced the
possibility that beyond the inherent information contained within the nucleotide sequence …

Culture expansion of primary cells evokes highly reproducible DNA methylation (DNAm)
changes. We have identified CG dinucleotides (CpGs) that become continuously hyper-or …

Background Genomic methylation patterns are established during gametogenesis, and
perpetuated in somatic cells by faithful maintenance methylation. There have been previous …

Background The DNA methylation profiles of mammalian cell lines differ from those of the
primary tissues from which they were derived, exhibiting increasing divergence from the in …

DNA methylation on cytosine is an epigenetic modification and is essential for gene
regulation and genome stability in vertebrates. Traditionally DNA methylation was …

During embryonic development a large number of widely differing and specialized cell types
with identical genomes are generated from a single totipotent zygote. Tissue specific …