The aim of pharmacology has traditionally been to develop compounds that could mimic,
activate or antagonize the molecules that control and regulate the physiological state of an …

The relationship between levels of DNA methylation and gene activity has been known for
some time. Many of the early procedures developed gave only somewhat limited information …

DNA methylation is a covalent modification of DNA that plays an important role in setting
gene expression programs during development. Recent evidence suggests that changes in …

DNA methylation is essential for normal embryonic development. Distinctive genomic
methylation patterns must be formed and maintained with high fidelity to ensure the …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

Methylation of DNA at 5-position of cytosine, catalyzed by DNA methyltransferases, is the
predominant epigenetic modification in mammals. Aberrations in methylation play a causal …

During the past few decades we have witnessed an era of remarkable growth in the field of
molecular biology. In 1950 very little was known of the chemical constitution of biological …

DNA methyltransferase inhibitors represent promising new drugs for cancer therapies. The
first of these compounds (5-azacytidine, Vidaza) has recently been approved as an …

The pharmacological inhibition of DNA methyltransferases provides novel opportunities for
the therapy of human cancers. Several Phase III trials of DNA methyltransferase inhibitors …

Changes in DNA methylation patterns play an important role in tumorigenesis. The DNA
methyltransferase 1 (DNMT1) protein represents a major DNA methyltransferase activity in …