All benzodiazepines enter cerebral tissue rapidly. However, the duration of action is short for
diazepam (< 2 hours) and midazolam (3 to 4 hours) and longer for clonazepam (24 hours) …

Management of seizure emergencies substantially changed after the introduction of rectal
diazepam in Europe in the 1970s and in the United States in the 1990s. Although safe and …

Time plays a major role in seizure evaluation and treatment. Acute repetitive seizures and
status epilepticus are medical emergencies that require immediate assessment and …

Benzodiazepines represent the first-line treatment for the acute management of epileptic
seizures and status epilepticus. The emergency use of benzodiazepines must be timely, and …

Status epilepticus (SE) is an acute, life-threatening medical condition that requires
immediate, effective therapy. Therefore, the acute care of prolonged seizures and SE is a …

Benzodiazepines (BZDs) remain important agents in the management of epilepsy. They are
drugs of first choice for status epilepticus and seizures associated with post‐anoxic insult …

Benzodiazepines are potent and effective drugs for the management of acute seizures and
status epilepticus. Lorazepam, diazepam, and clonazepam have been the most widely …

Intravenous and intramuscular antiseizure drugs (ASDs) are essential in the treatment of
clinical seizure emergencies as well as in replacement therapy when oral administration is …

Early treatment of prolonged seizures with benzodiazepines given intravenously by
paramedics in the prehospital setting had been shown to be associated with improved …

Factors influencing the rate and extent of benzodiazepine uptake into cerebrospinal fluid
(CSF), peripheral tissue distribution and electroencephalographic (EEG) effects were …