Hearing loss is the most frequent sensory deficit in the human population and can occur at
any age. Hearing loss ranges from mild to profound, can be conductive, sensorineural or …

Twenty years have passed since the discovery of hair cell regeneration in birds (Corwin &
Cotanche, 1988; Ryals & Rubel, 1988). The initial excitement caused by this discovery has …

Understanding the complex pathologies associated with hearing loss is a significant
motivation for conducting inner ear research. Lifelong exposure to loud noise, ototoxic …

Hearing loss affects hundreds of millions of people worldwide by dampening or cutting off
their auditory connection to the world. Current treatments for sensorineural hearing loss …

Hair cells (HCs) are vertebrate sensory mechanoreceptors that detect signals from the
environment associated with hearing, balance, body orientation, and external water …

The sensory cells of the ear, the hair cells, are damaged by loud noise or certain types of
drugs. In the bird cochlea, new hair cells are produced to replace those that are lost …

We explore the changes in chromatin accessibility and transcriptional programs for cochlear
hair cell differentiation from postmitotic supporting cells using organoids from postnatal …

We explored the transcriptional and epigenetic programs underlying the differentiation of
hair cells from postnatal progenitor cells in cochlear organoids. Heterogeneity in the cells …

The study of an adult mammalian auditory system, such as regeneration, has been
hampered by the lack of an in vitro system in which hypotheses can be tested efficiently. This …

In mammals, hair cells may be damaged or lost due to genetic mutation, infectious disease,
chemical ototoxicity, noise and other factors, causing permanent sensorineural deafness …