The first systematic, functional screens to identify the genes involved in vertebrate
embryogenesis have been completed in the zebrafish, Danio rerio. In an extraordinary issue …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

The identification of genes via their mutant phenotypes is the most direct way of dissecting
the molecular basis of developmental processes. While this approach has been extremely …

Exquisite embryonic lethal mutations have been isolated in hundreds of genes necessary for
zebrafish development. Analysis of this resource promises to enhance our understanding of …

The diploid genome of mice or zebrafish presents a time-consuming problem to geneticists.
After individual heterozygous founder animals have been generated, F t families must be …

The zebrafish (Danio rerio) has proven its worth as an excellent model system for the study
of vertebrate development. In 1996, in an issue of the journal Development, the results of the …

Two recent large-scale genetic screens in zebrafish have identified many mutations that
affect differentiation in a variety of organ systems, particularly the notochord, the neural crest …

The zebrafish has become an important model for studying early vertebrate development.
This is largely because of the pioneering work of George Streisinger and the later work of his …

Systematic genome-wide mutagenesis screens for embryonic phenotypes have been
instrumental in the understanding of invertebrate and plant development. Here, we report …

A screen for developmentally regulated genes was conducted in the zebrafish, a system
offering substantial advantages for the study of the molecular genetics of vertebrate …