It is well known that melatonin plays a fundamental role in human neuro‐
immunomodulation. Thus, melatonin regulates the production of a large number of …

Human lymphocyte melatonin, through membrane and nuclear receptors binding, acts as an
activator in IL-2 production. Antagonism of membrane melatonin receptors using luzindole …

Human lymphocytes have recently been described as an important physiological source of
melatonin (N‐acetyl‐5‐methoxytryptamine), which could be involved in the regulation of the …

Since melatonin was first isolated in 1958 up to the last few years, this substance was
considered a hormone exclusive to the pineal gland. Although melatonin has lately been …

Melatonin has been proposed as regulating the immune system by affecting cytokine
production in immunocompetent cells, enhancing the production of several T helper (Th) 1 …

Many functional studies show that melatonin plays a fundamental role in
neuroimmunomodulation. In this paper, we have extended our studies on the influence of …

This report shows that melatonin enhances IL-6 production by U937 cells via a nuclear
receptor-mediated mechanism. Resting U937 cells only express membrane (mt1) melatonin …

Melatonin is hypothesized to play a role in neuroimmunomodulation. This study investigated
the in vitro effects of melatonin (10− 12–10− 6 M) on human peripheral blood mononuclear …

Melatonin could act on immune system by regulating cytokine production of
immunocompetent cells. The hormone enhances IL-2, IFN-γ and IL-6 production by cultured …

Evidence in support of melatonin's role as an immunomodulator is incomplete and, in some
cases, contradictory. The present studies determined whether melatonin modulates the …