Estimated doses of melatonin for treating deadly virus infections: focus on COVID-19

DX Tan, R Hardeland - Melatonin Research, 2020 - melatonin-research.net
Increased evidence implies that melatonin may be a promising molecule for combating
COVID-19 due to its potent antioxidative, anti-inflammatory and immunoregulatory …

[HTML][HTML] Therapeutic algorithm for use of melatonin in patients with COVID-19

RJ Reiter, P Abreu-Gonzalez, PE Marik… - Frontiers in …, 2020 - frontiersin.org
The coronavirus, COVID-19, has infected hundreds of thousands and killed tens of
thousands of individuals worldwide. This highly infectious condition continues to ravage the …

Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality

DX Tan, RJ Reiter - Life Sciences, 2022 - Elsevier
The fear of SARS-CoV-2 infection is due to its high mortality related to seasonal flu. To date,
few medicines have been developed to significantly reduce the mortality of the severe …

Clinical trial to test the efficacy of melatonin in COVID‐19

D Acuña‐Castroviejo, G Escames… - Journal of pineal …, 2020 - Wiley Online Library
The pharmacological properties of melatonin are well known. However, there is noticeable
the lack of clinical trials that confirm the efficacy, security, absence of side effects in the short …

Clinical trials for use of melatonin to fight against COVID-19 are urgently needed

K Kleszczyński, AT Slominski, K Steinbrink, RJ Reiter - Nutrients, 2020 - mdpi.com
The recent pandemic of COVID-19 has already infected millions of individuals and has
resulted in the death of hundreds of thousands worldwide. Based on clinical features …

Melatonin reduces the mortality of severely-infected COVID-19 patients

DX Tan, RJ Reiter - Melatonin Research, 2021 - melaonin-research.com
SARS-CoV-2 has ravaged the population of the world for two years. Scientists have not yet
identified an effective therapy to reduce the mortality of severe COVID-19 patients. In a …

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

DX Tan, R Hardeland - Melatonin Research, 2020 - melatonin-research.net
The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19,
and avian flu is often caused by the uncontrolled innate immune response and destructive …

Melatonin potentials against viral infections including COVID-19: Current evidence and new findings

KB Juybari, MH Pourhanifeh, A Hosseinzadeh… - Virus research, 2020 - Elsevier
Viral infections are dangerous diseases for human health worldwide, which lead to
significant morbidity and mortality each year. Because of their importance and the lack of …

[HTML][HTML] Melatonin use for SARS‐CoV‐2 infection: Time to diversify the treatment portfolio

RJ Reiter, R Sharma, DX Tan, RL Neel… - Journal of Medical …, 2022 - ncbi.nlm.nih.gov
To the Editor, We were pleased to read the publication by Lan et al. 1 which included a meta‐
analysis of the randomized controlled trials (RCTs) in which melatonin was used as a …

Melatonin and Covid-19: An opened Pandora's box and the hope for the time being

L Chacín-Bonilla, E Bonilla - Melatonin Research, 2023 - melatonin-research.net
The SARS-CoV-2 pandemic is a global health concern still ongoing. No single therapeutic
intervention with high efficacy exists and virus mutations continue to improve immune …