Complex cytoplasmic nucleotide-sensing mechanisms can recognize foreign DNA based on
a lack of methylation and initiate an immune response to clear the infection. Zebrafish …

Activation of transposable elements (TEs) can cause cellular damage. Cytoplasmic nucleic
acid sensing pathways evolved to detect pathogens, but can also serve to cull cells with …

DNA methylation reprogramming, the erasure of DNA methylation patterns shortly after
fertilization and their reestablishment during subsequent early development, is essential for …

DNA methylation is crucial for normal development and cellular differentiation in many large-
genome eukaryotes. The small tropical freshwater fish Danio rerio (zebrafish) has recently …

UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to
hemimethylated DNA during replication and is essential for maintaining DNA methylation …

Parasites are arguably among the strongest drivers of natural selection, constraining hosts
to evolve resistance and tolerance mechanisms. Although, the genetic basis of adaptation to …

The mechanisms responsible for active DNA demethylation remain elusive in Metazoa. A
previous study that utilized zebrafish embryos provided a potent mechanism for active …

DNA methylation is a prevalent epigenetic modification in vertebrates, and it has been
shown to be involved the regulation of gene expression and embryo development. However …

DNA methylation is an important epigenetic modification that has been repeatedly implied in
organismal adaptation. However, many previous studies that have linked DNA methylation …

Post-fertilization epigenome reprogramming erases epigenetic marks transmitted through
gametes and establishes new marks during mid-blastula stages. The mouse embryo …