Epigenetic changes represent a potential mechanism underlying associations of early-life
exposures and later life health outcomes. Population-based cohort studies starting in early …

Changes in DNA methylation are involved in development, disease, and the response to
environmental conditions. However, not all regulatory elements are functionally methylation …

Alterations in DNA methylation have been implicated in mammalian development. Hence,
the identification of tissue-specific differentially methylated regions (TDMs) is indispensable …

DNA methylation is an essential epigenetic mark whose role in gene regulation and its
dependency on genomic sequence and environment are not fully understood. In this study …

Early studies proposed that DNA methylation could have a role in regulating gene
expression during development [Riggs, AD (1975) Cytogenet. Cell Genet. 14, 9–25] …

Background Development of human tissue is influenced by a combination of intrinsic
biological signals and extrinsic environmental stimuli, both of which are mediated by …

Infants undergo extensive developments during their first year of life. Although the biological
mechanisms involved are not yet fully understood, changes in the DNA methylation in …

Parent-specific differentially methylated regions (DMRs) are established during
gametogenesis and regulate parent-specific expression of imprinted genes. Monoallelic …

DNA methylation is a crucial layer of epigenetic regulation during mammalian embryonic
development,–. Although the DNA methylome of early human embryos has been analyzed …

Background DNA methylation has been recognized as a key mechanism in cell
differentiation. Various studies have compared tissues to characterize epigenetically …