Melatonin binds and activates G protein‐coupled melatonin receptors. The density and
affinity of the endogenous melatonin receptors change throughout the 24‐hr day, and the …

In mammals, the pineal hormone melatonin activates G protein-coupled MT1 and MT2
melatonin receptors. Acute exposure of recombinant MT1 and MT2 melatonin receptors to …

Melatonin mediates its physiological effects through activation of high affinity G protein-
coupled receptors. The vertebrate MT1, MT2 and Mel1c melatonin receptors are molecularly …

In mammals, melatonin activates melatonin MT1 and MT2 receptors. Using site-directed
mutagenesis and chemical modification, we investigated the role of conserved cysteines in …

Melatonin, a molecule implicated in a variety of diseases, including cancer, often exerts its
effects through G‐protein‐coupled melatonin receptors, MT1 and MT2. In this study, we …

Melatonin receptors bind and become activated by melatonin. The melatonin-related
receptor, despite sharing considerable amino acid sequence identity with melatonin …

All G protein‐coupled melatonin receptors have two conserved cysteines in the interphase
between transmembrane helix III and the second intracellular loop, in the region assumed …

Melatonin receptors have been described to activate different G protein–dependent
signaling pathways, both in laboratory, heterologous, cellular models and in physiological …

Estrogen modulates expression and function of G-protein-coupled receptors. The goal of this
study was to assess the effect of 17β-estradiol (10 nM) exposure for 1 (E1) or 6 (E6) days on …

Melatonin MT 1 and MT 2 receptors are Gi protein-coupled receptors and promising
therapeutic targets for a number of diseases. A proportion of G protein-coupled receptor …