[HTML][HTML] Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development
MM Dawlaty, A Breiling, T Le, G Raddatz, MI Barrasa… - Developmental cell, 2013 - cell.com
Summary Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for …
hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for …
[HTML][HTML] Loss of Tet enzymes compromises proper differentiation of embryonic stem cells
MM Dawlaty, A Breiling, T Le, MI Barrasa, G Raddatz… - Developmental cell, 2014 - cell.com
Summary Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC) and are dynamically expressed during development …
hydroxymethylcytosine (5hmC) and are dynamically expressed during development …
[HTML][HTML] Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development
The Tet family of enzymes (Tet1/2/3) converts 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC). Mouse embryonic stem cells (mESCs) highly express Tet1 …
hydroxymethylcytosine (5hmC). Mouse embryonic stem cells (mESCs) highly express Tet1 …
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation
Mammalian development begins in transcriptional silence followed by a period of
widespread activation of thousands of genes. DNA methylation reprogramming is integral to …
widespread activation of thousands of genes. DNA methylation reprogramming is integral to …
TET enzymes, DNA demethylation and pluripotency
SE Ross, O Bogdanovic - Biochemical Society Transactions, 2019 - portlandpress.com
Ten-eleven translocation (TET) methylcytosine dioxygenases (TET1, TET2, TET3) actively
cause demethylation of 5-methylcytosine (5mC) and produce and safeguard …
cause demethylation of 5-methylcytosine (5mC) and produce and safeguard …
[HTML][HTML] Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells
TET family enzymes convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in
DNA. Here, we show that Tet1 and Tet2 are Oct4-regulated enzymes that together sustain …
DNA. Here, we show that Tet1 and Tet2 are Oct4-regulated enzymes that together sustain …
Tet1 and 5-hydroxymethylation: a genome-wide view in mouse embryonic stem cells
Inner cell mass (ICM) cells of a blastocyst, the source of embryonic stem (ES) cells, are
characterized by their unique ability to give rise to all cell types in adult organisms. The …
characterized by their unique ability to give rise to all cell types in adult organisms. The …
[HTML][HTML] Tet enzymes, variants, and differential effects on function
P Melamed, Y Yosefzon, C David… - Frontiers in cell and …, 2018 - frontiersin.org
Discovery of the ten-eleven translocation 1 (TET) methylcytosine dioxygenase family of
enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the …
enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the …
[HTML][HTML] Delineation of a human Mendelian disorder of the DNA demethylation machinery: TET3 deficiency
DB Beck, A Petracovici, C He, HW Moore… - The American Journal of …, 2020 - cell.com
Germline pathogenic variants in chromatin-modifying enzymes are a common cause of
pediatric developmental disorders. These enzymes catalyze reactions that regulate …
pediatric developmental disorders. These enzymes catalyze reactions that regulate …
[HTML][HTML] Isoform switch of TET1 regulates DNA demethylation and mouse development
The methylcytosine oxidase TET proteins play important roles in DNA demethylation and
development. However, it remains elusive how exactly they target substrates and execute …
development. However, it remains elusive how exactly they target substrates and execute …