DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …

Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …

Virtually all mammalian species including mouse, rat, pig, cow, and human, but not sheep
and rabbit, undergo genome‐wide epigenetic reprogramming by demethylation of the male …

The fertilized mouse egg actively demethylates the paternal genome within a few hours after
fertilization, whereas the maternal genome is only passively demethylated by a replication …

We have examined the relative methylation levels of several dispersed repeated and low-
copy-number gene sequences during gametogenesis and early embryogenesis. Southern …

Several lines of evidence strongly suggest that DNA methylation is involved in embryo
development. Perhaps the most direct evidence comes from experiments with …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

Methylation of DNA, which occurs at cytosines of CpG sequences, is a unique chemical
modification of the vertebrate genome. Methylation patterns can be copied to daughter DNA …

The levels of genomic DNA methylation in vertebrate species display a wide range of
developmental dynamics. Here, we show that in contrast to mice, the paternal genome of the …

We have examined the methylation status of the zebrafish genome during early
embryogenesis and we find evidence that methylation fluxes do occur in that organism. The …