The prevalence, the prognostic effect, and interaction with other molecular markers of
DNMT3A mutations was studied in 415 patients with acute myeloid leukemia (AML) younger …

DNMT3A mutations are associated with poor prognosis in acute myeloid leukemia (AML),
but the stability of this mutation during the clinical course remains unclear. In the present …

Purpose To determine the frequency of DNMT3A mutations, their associations with clinical
and molecular characteristics and outcome, and the associated gene-and microRNA …

In this study, we evaluated the frequency and prognostic impact of DNMT3A mutations
(DNMT3A mut) in 1770 younger adult patients with acute myeloid leukemia (AML) in the …

Background The genetic alterations responsible for an adverse outcome in most patients
with acute myeloid leukemia (AML) are unknown. Methods Using massively parallel DNA …

Somatic mutations of DNMT3A gene have recently been reported in acute myeloid leukemia
(AML) and myelodysplastic syndrome (MDS). We examined the entire coding sequences of …

Objectives: Recently, mutations in DNMT3A gene have been described in about 25% acute
myeloid leukemia (AML) cases, preferentially in monocytic AML. They were found to predict …

Purpose To study the incidence and prognostic impact of mutations in DNA
methyltransferase 3A (DNMT3A) in patients with acute myeloid leukemia. Patients and …

Abstract Recently, DNA methyltransferase 3A (DNMT3A) mutations have been identified in
acute myeloid leukemia (AML), the highest frequency being found within cytogenetically …

Purpose To evaluate the impact of DNMT3A mutations on outcome in younger patients with
cytogenetic intermediate-risk acute myeloid leukemia. Patients and Methods Diagnostic …