X-chromosome inactivation (XCI) is a dosage compensation mechanism that silences the
majority of genes on one X chromosome in each female cell. To characterize epigenetic …

X-chromosome inactivation (XCI) results in the differential marking of the active and inactive
X with epigenetic modifications including DNA methylation. Consistent with the previous …

X-chromosome inactivation (XCI) achieves dosage compensation between males and
females through the silencing of the majority of genes on one of the female X chromosomes …

Background X-chromosome inactivation (XCI) results in the silencing of most genes on one
X chromosome, yielding mono-allelic expression in individual cells. However, random XCI …

Counting chromosomes is not just simple math. Although normal males and females differ in
sex chromosome content (XY vs. XX), X chromosome imbalance is tolerated because …

X-chromosome inactivation (XCI) provides a dosage compensation mechanism where, in
each female cell, one of the two X chromosomes is randomly silenced. However, some …

A number of recent studies have provided new insights into mechanisms that regulate
genomic imprinting in the mammalian genome. Regions of allele-specific differential …

X-chromosome inactivation is a remarkable epigenetic event in mammalian females that
results in the transcriptional silencing of one of the pair of X chromosomes. However, not all …

Xist (X-inactive specific transcript) plays a crucial role in X-inactivation. This non-coding RNA
becomes upregulated on the X chromosome that is to be inactivated upon differentiation …

X chromosome inactivation (XCI) silences most genes on one X chromosome in female
mammals, but some genes escape XCI. To identify escape genes in vivo and to explore …