X chromosome (X) inactivation is a remarkable biological process including the choice and
cis‐limited inactivation of one X, as well as the stable maintenance of this silencing by …

The" inactive" X chromosome (Xi) has been assumed to have little impact, in trans, on the"
active" X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one …

Background X chromosome inactivation is the epigenetic silencing of the majority of the
genes on one of the X chromosomes in XX therian mammals. In humans, approximately …

X chromosome inactivation (XCI) is the transcriptional silencing of the majority of genes on
one of the two X chromosomes in mammalian females. Females are, therefore, mosaics for …

Genes on the mammalian X chromosome are present in one copy in males and two copies
in females. The complex mechanisms that regulate the X chromosome lead to evolutionary …

Background In mammals, one of the female X chromosomes and all imprinted genes are
expressed exclusively from a single allele in somatic cells. To evaluate structural changes …

Skewing of X chromosome inactivation (XCI) can occur in normal females and increases in
tissues with age. The mechanisms underlying skewing in normal females, however, remain …

Abstract Background Sex chromosome aneuploidies (SCAs) give rise to a broad range of
phenotypic traits and diseases. Previous studies based on peripheral blood samples have …

A significant number of human X-linked genes escape X chromosome inactivation and are
thus expressed from both the active and inactive X chromosomes. The basis for escape from …

X chromosome inactivation (XCI) is an essential mechanism for dosage compensation of X-
linked genes in female cells. We report that subcultures from lines of female human …