DNA methylation changes are among the most common detectable abnormalities in human
neoplasia. Hypermethylation within the promoters of selected genes appears to be …

DNA methylation provides a major epigenetic code (besides histone modification) of the
lineage-and developmentspecific genes (such as regulators of differentiation in the …

DNA methylation abnormalities have recently emerged as one of the most frequent
molecular changes in hematopoietic neoplasms. Since methylation and transcriptional …

Inactivation of tumor suppressor genes is an important event contributing to the development
of neoplasia. In addition to the classic genetic mechanisms of deletion or inactivating point …

Targeting DNA methylation for cancer therapy has had a rocky history. The first reports on
DNA methylation changes in cancer described global loss of methylation, which has been …

Methylation of DNA is a biochemical modification that can influence gene expression and is
involved in inactivating one of the two X chromosomes in women. Evidence that has …

The rapid advances in high‐throughput sequencing technologies have made it more evident
that epigenetic modifications orchestrate a plethora of complex biological processes. During …

Purpose: Aberrant methylation of the 5′ gene promoter regions is an epigenetic
phenomenon that is the major mechanism for silencing of tumor suppressor genes in many …

We are at the dawn of an era when epigenetic drugs will be an important weapon in our
arsenal in the war against cancer. Hematological malignancies have provided a promising …

Hypermethylation of CpG islands near gene promoter regions is associated with
transcriptional inactivation and represents an important mechanism of gene silencing in …