Previous studies have implicated ferric reduction in the iron uptake pathway of the
opportunistic pathogen Cryptococcus neoformans. Here we studied iron uptake directly …

The pathogenic yeast Cryptococcus neoformans must reduce Fe (III) to Fe (II) prior to uptake.
We investigated mechanisms of reduction using the chromogenic ferrous chelator …

Highlights•C. neoformans possesses high-affinity and low-affinity iron uptake systems.•The
reductive high-affinity iron uptake system is required for virulence.•The regulation of iron …

Iron is an essential element for the growth and metabolism of microbial cells. Most
pathogenic microbes elaborate powerful iron chelating agents (siderophores) to mobilize …

Low-iron minimal medium supported growth of Cryptococcus neoformans but spent medium
contained no hydroxamates, organic acids or other iron chelators. Exogenous deferoxamine …

We studied the effects of iron chelators and of a thallium salt on growth of Cryptococcus
neoformans in defined medium. An oxidant-sensitive mutant strain was found to require …

Iron acquisition is a critical aspect of the virulence of many pathogenic microbes, and iron
limitation is an important defense mechanism for mammalian hosts. We are examining …

Cryptococcus neoformans is a pathogenic yeast that causes meningitis in
immunocompromised patients. Because iron acquisition is critical for growth of a pathogen …

Iron acquisition is critical for the ability of the pathogenic yeast Cryptococcus neoformans to
cause disease in vertebrate hosts. In particular, iron overload exacerbates cryptococcal …

The acquisition of iron from mammalian hosts is an important aspect of infection because
microbes must compete with the host for this nutrient and iron perception often regulates …