Integrins are a large family of transmembrane receptors for extracellular matrix (ECM)
molecules. They play a critical role in organ morphogenesis, physiology and pathology, as …

The extracellular matrix (ECM) exerts important effects on cell function that play a vital role in
such diverse processes as embryogenesis, wound healing, cancer metastasis, and …

Integrin-linked kinase has emerged as a key player at the interface between extracellular
matrix, integrins, actin-based cytoskeleton and cellular phenotype in kidney diseases. Future …

Integrins are heterodimeric cell surface receptors that mediate heterophilic cell-cell
interactions and interactions between cells and the extracellular matrix (Hynes RO. Cell 69 …

Glomerular mesangial cells play a central role in maintaining structure and function of the
glomerular capillary ultrafiltration apparatus. Under physiological and pathological …

Integrins represent a superfamily of cell surface molecules that are important mediators of
cell-extracellular matrix interactions. Of the many known integrin subunit combinations, only …

We present genetic evidence that integrins regulate epithelial–mesenchymal interactions
during organogenesis. Mice with a mutation in the α8 gene do not express the integrin α8β1 …

Background Extracellular matrix receptors of the integrin family are known to regulate cell
adhesion, shape and functions. The α8 integrin chain is expressed in glomerular mesangial …

A major hallmark of chronic kidney injury is fibrosis, which is characterized by increased
accumulation of extracellular matrix components that replace the damaged tissue. Normally …

Integrins are heterodimeric transmembrane receptors for extracellular matrix (ECM)
components and they link the intracellular actin cytoskeleton to the cellular environment …