Comparison of pre-processing methodologies for Illumina 450k methylation array data in familial analyses
Background Human methylome mapping in health and disease states has largely relied on
Illumina Human Methylation 450k array (450k array) technology. Accompanying this has …
Illumina Human Methylation 450k array (450k array) technology. Accompanying this has …
A data-driven approach to preprocessing Illumina 450K methylation array data
Background As the most stable and experimentally accessible epigenetic mark, DNA
methylation is of great interest to the research community. The landscape of DNA …
methylation is of great interest to the research community. The landscape of DNA …
Collapsed methylation quantitative trait loci analysis for low frequency and rare variants
TG Richardson, HA Shihab, G Hemani… - Human molecular …, 2016 - academic.oup.com
Background: Single variant approaches have been successful in identifying DNA
methylation quantitative trait loci (mQTL), although as with complex traits they lack the …
methylation quantitative trait loci (mQTL), although as with complex traits they lack the …
Batch-effect detection, correction and characterisation in Illumina HumanMethylation450 and MethylationEPIC BeadChip array data
Background Genomic technologies can be subject to significant batch-effects which are
known to reduce experimental power and to potentially create false positive results. The …
known to reduce experimental power and to potentially create false positive results. The …
DMRforPairs: identifying differentially methylated regions between unique samples using array based methylation profiles
MA Rijlaarsdam, YG van der Zwan, LCJ Dorssers… - BMC …, 2014 - Springer
Background Array based methylation profiling is a cost-effective solution to study the
association between genome methylation and human disease & development. Available …
association between genome methylation and human disease & development. Available …
Comparison of clustering methods for investigation of genome-wide methylation array data
H Clifford, F Wessely, S Pendurthi, RD Emes - Frontiers in genetics, 2011 - frontiersin.org
The use of genome-wide methylation arrays has proved very informative to investigate both
clinical and biological questions in human epigenomics. The use of clustering methods …
clinical and biological questions in human epigenomics. The use of clustering methods …
Identifying mislabeled and contaminated DNA methylation microarray data: an extended quality control toolset with examples from GEO
JA Heiss, AC Just - Clinical epigenetics, 2018 - Springer
Background Mislabeled, contaminated or poorly performing samples can threaten power in
methylation microarray analyses or even result in spurious associations. We describe a set …
methylation microarray analyses or even result in spurious associations. We describe a set …
A systematic assessment of normalization approaches for the Infinium 450K methylation platform
The Illumina Infinium HumanMethylation450 BeadChip has emerged as one of the most
popular platforms for genome wide profiling of DNA methylation. While the technology is …
popular platforms for genome wide profiling of DNA methylation. While the technology is …
MethLAB: a graphical user interface package for the analysis of array-based DNA methylation data
Recent evidence suggests that DNA methylation changes may underlie numerous complex
traits and diseases. The advent of commercial, array-based methods to interrogate DNA …
traits and diseases. The advent of commercial, array-based methods to interrogate DNA …
Comparison of methyl-capture sequencing vs. Infinium 450K methylation array for methylome analysis in clinical samples
Interindividual variability in the epigenome has gained tremendous attention for its potential
in pathophysiological investigation, disease diagnosis, and evaluation of clinical …
in pathophysiological investigation, disease diagnosis, and evaluation of clinical …