Aberrant DNA methylation is associated with cancer development and progression. There
are several types of specimens from which DNA methylation pattern can be measured and …

DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …

A recent expansion of our knowledge about epigenetic changes strongly suggests that
epigenetic rather than genetic features better reflect disease development, and …

Cancer contributes to a large proportion of the mortality and morbidity in the United States
and worldwide. Despite advances in diagnosis and treatment of various cancers, early …

Multiple studies have investigated global DNA methylation profiles and gene-specific DNA
methylation in blood-based DNA to develop powerful screening markers for cancer. This …

Early detection appears to be one of the most important approaches to reducing mortality
caused by neoplasia. Changes in DNA methylation have been recognized as one of the …

Epigenetic alterations by promoter DNA hypermethylation and gene silencing in cancer
have been reported over the past few decades. DNA hypermethylation has great potential to …

Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …

Background Good biomarkers for early detection of cancer lead to better prognosis.
However, harvesting tumor tissue is invasive and cannot be routinely performed. Global …

Epigenetic silencing by promoter methylation of genes associated with cancer initiation and
progression is a hallmark of tumour cells. As a consequence, testing for DNA methylation …