Prediction of genome-wide DNA methylation in repetitive elements
DNA methylation in repetitive elements (RE) suppresses their mobility and maintains
genomic stability, and decreases in it are frequently observed in tumor and/or surrogate …
genomic stability, and decreases in it are frequently observed in tumor and/or surrogate …
Methods for genome-wide DNA methylation analysis in human cancer
S Fan, W Chi - Briefings in Functional Genomics, 2016 - academic.oup.com
Aberrant DNA methylation is considered to be one of the most common hallmarks of cancer.
Several recent advances in assessing the DNA methylome provide great promise for …
Several recent advances in assessing the DNA methylome provide great promise for …
Cytosine methylation profiling of cancer cell lines
DNA-methylation changes in human cancer are complex and vary between the different
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
Tumour class prediction and discovery by microarray-based DNA methylation analysis
P Adorján, J Distler, E Lipscher, F Model… - Nucleic acids …, 2002 - academic.oup.com
Aberrant DNA methylation of CpG sites is among the earliest and most frequent alterations
in cancer. Several studies suggest that aberrant methylation occurs in a tumour type-specific …
in cancer. Several studies suggest that aberrant methylation occurs in a tumour type-specific …
Modeling complex patterns of differential DNA methylation that associate with gene expression changes
CE Schlosberg, ND VanderKraats… - Nucleic acids …, 2017 - academic.oup.com
Numerous genomic studies are underway to determine which genes are abnormally
regulated by DNA methylation in disease. However, we have a poor understanding of how …
regulated by DNA methylation in disease. However, we have a poor understanding of how …
Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer
Background There is growing evidence that DNA methylation alterations contribute to
carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the …
carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the …
Gene-set analysis is severely biased when applied to genome-wide methylation data
Motivation: DNA methylation is an epigenetic mark that can stably repress gene expression.
Because of its biological and clinical significance, several methods have been developed to …
Because of its biological and clinical significance, several methods have been developed to …
MEDME: an experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment
M Pelizzola, Y Koga, AE Urban… - Genome …, 2008 - genome.cshlp.org
DNA methylation is an important component of epigenetic modifications that influences the
transcriptional machinery and is aberrant in many human diseases. Several methods have …
transcriptional machinery and is aberrant in many human diseases. Several methods have …
MethylMix 2.0: an R package for identifying DNA methylation genes
DNA methylation is an important mechanism regulating gene transcription, and its role in
carcinogenesis has been extensively studied. Hyper and hypomethylation of genes is a …
carcinogenesis has been extensively studied. Hyper and hypomethylation of genes is a …
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm
DNA methylation plays key roles in diverse biological processes such as X chromosome
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …