DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …

In vertebrates, the biological consequences of DNA methylation are often mediated by
protein factors containing conserved methyl-CpG binding domains (MBDs). Mutations in the …

DNA methylation at CpG dinucleotides is an important epigenetic regulator common to
virtually all mammalian cell types, but recent evidence indicates that during early postnatal …

Abstract Methylated CpG Binding Protein 2 (MeCP2) is a nuclear protein named for its ability
to selectively recognize methylated DNA. Much attention has been focused on …

DNA methylation is an epigenetic modification that is implicated in transcriptional silencing.
It is becoming increasingly clear that both correct levels and proper interpretation of DNA …

Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …

Mutations of the methylated DNA binding protein MeCP2, a multifunctional protein that is
thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the …

Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-
cytosine binding domain (MBD), which preferentially binds to methylated CpG dinucleotides …

CpG methylation, the most common epigenetic modification of vertebrate genomes, is
primarily associated with transcriptional repression. MeCP2, MBD1, MBD2, MBD3 and …

CpG methylation in vertebrates is important for gene silencing, alterations in chromatin
structure and genomic stability, and differences in the DNA-methylation status are correlated …