Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome
(RTT), a rare neurodevelopmental disorder with a notable period of developmental …

The discovery that Rett syndrome is caused by mutations that affect the methyl-CpG-binding
protein MeCP2 provided a major breakthrough in understanding this severe …

Epigenetic mechanisms, such as DNA methylation, regulate transcriptional programs to
afford the genome flexibility in responding to developmental and environmental cues in …

Methylation of cytosine in human DNA has been studied for over 60 years, but has only
recently been confirmed as an important player in human disease. Rett syndrome is a …

The methyl-CpG binding proteins (MBPs) interpret the methylation of DNA and its
components. The number of MBPs in the human body currently stands at 15, which are split …

Core members of the MBD protein family (MeCP2, MBD1, MBD2 and MBD4) share a methyl-
CpG-binding domain that has a specific affinity for methylated CpG sites in double-stranded …

During mammalian cell division, DNA methylation patterns are transferred accurately to the
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase …

DNA methylation is involved in a variety of genome functions, including gene control and
chromatin dynamics. MBD1 is a transcriptional regulator through the cooperation of a methyl …

MeCP2 is a chromosomal protein that is concentrated in the centromeric heterochromatin of
mouse cells. In vitro, the protein binds preferentially to DNA containing a single …

Abstract Background Methylation at CpG dinucleotides in genomic DNA is a fundamental
epigenetic mechanism of gene expression control in vertebrates. Proteins with a methyl …