MBD1, a member of the methyl-CpG-binding domain family of proteins, has been reported to
repress transcription of methylated and unmethylated promoters. As some MBD1 isoforms …

Mecp2 is an X-linked gene encoding a nuclear protein that binds specifically to methylated
DNA (ref. 1) and functions as a general transcriptional repressor by associating with …

Rett syndrome is a dominant neurological disorder caused by loss-of-function mutations of
methyl-CpG-binding protein 2 (MeCP2). MeCP2 is an abundant chromatin-associated …

Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …

We have investigated the properties of mutant forms of the methyl-CpG binding
transcriptional repressor MeCP2 associated with Rett syndrome, a childhood …

Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved
in regulating transcription and chromatin structure, controlling the spread of parasitic …

Methylation of genomic CpG residues is crucial for proper neuronal function. Rett syndrome,
a common form of mental retardation, is associated with mutations in the gene encoding …

The role of DNA methylation in brain development is an intense area of research because
the brain has particularly high levels of CpG and mutations in many of the proteins involved …

DNA methylation occurs in bacteria, fungi, plants and animals, however its role varies widely
among different organisms. Even within animal genomes, methylation patterns vary …

The effects of DNA methylation on transcription and chromatin structure require that nuclear
factors be able to distinguish methylated and nonmethylated DNA. We describe a nMhyWpG …