Mecp2 is an X-linked gene encoding a nuclear protein that binds specifically to methylated
DNA (ref. 1) and functions as a general transcriptional repressor by associating with …

Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved
in regulating transcription and chromatin structure, controlling the spread of parasitic …

hMeCP2 (human methylated DNA-binding protein 2), mutations of which cause most cases
of Rett syndrome (RTT), is involved in the transmission of repressive epigenetic signals …

DNA methylation and chromatin modification are two global mechanisms that regulate gene
expression. Recent studies provide insight into the mechanism of transcriptional silencing by …

The role of DNA methylation in brain development is an intense area of research because
the brain has particularly high levels of CpG and mutations in many of the proteins involved …

Rett syndrome is a dominant neurological disorder caused by loss-of-function mutations of
methyl-CpG-binding protein 2 (MeCP2). MeCP2 is an abundant chromatin-associated …

We have investigated the properties of mutant forms of the methyl-CpG binding
transcriptional repressor MeCP2 associated with Rett syndrome, a childhood …

MBD1, a member of the methyl-CpG-binding domain family of proteins, has been reported to
repress transcription of methylated and unmethylated promoters. As some MBD1 isoforms …

Methylation of genomic CpG residues is crucial for proper neuronal function. Rett syndrome,
a common form of mental retardation, is associated with mutations in the gene encoding …

The effects of DNA methylation on transcription and chromatin structure require that nuclear
factors be able to distinguish methylated and nonmethylated DNA. We describe a nMhyWpG …