Urinary levels of trimethylamine‐N‐oxide and incident coronary heart disease: a prospective investigation among urban Chinese adults

D Yu, XO Shu, ES Rivera, X Zhang, Q Cai… - Journal of the …, 2019 - Am Heart Assoc
Background Trimethylamine‐N‐oxide (TMAO), a diet‐derived, gut microbial–host
cometabolite, has been associated with adverse cardiovascular outcomes in patient …

Gut microbiota-dependent trimethylamine-N-oxide (TMAO) shows a U-shaped association with mortality but not with recurrent venous thromboembolism

MF Reiner, D Müller, S Gobbato, O Stalder… - Thrombosis research, 2019 - Elsevier
Introduction Gut microbiota-dependent trimethylamine-N-oxide (TMAO) correlates with
arterial thrombotic events including myocardial infarction and stroke, and mortality. However …

Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target

MH Janeiro, MJ Ramírez, FI Milagro, JA Martínez… - Nutrients, 2018 - mdpi.com
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and
carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several …

Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular …

A Mafune, T Iwamoto, Y Tsutsumi, A Nakashima… - Clinical and …, 2016 - Springer
Abstract Background Trimethylamine-N-oxide (TMAO) is a metabolite of phosphatidylcholine
generated by gut microbiota and liver enzymes, and has recently been recognized as …

The role of microbiota in cardiovascular risk: focus on trimethylamine oxide

H Al-Rubaye, G Perfetti, JC Kaski - Current Problems in Cardiology, 2019 - Elsevier
The extensive collection of bacteria cohabiting within the host collaborates with human
functions and metabolisms in both health and disease. The fine equilibrium of commensals …

The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases

J Zhen, Z Zhou, M He, HX Han, EH Lv… - Frontiers in …, 2023 - frontiersin.org
Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

Serum trimethylamine-N-oxide is elevated in CKD and correlates with coronary atherosclerosis burden

JR Stubbs, JA House, AJ Ocque, S Zhang… - Journal of the …, 2016 - journals.lww.com
Abstract Trimethlyamine-N-oxide (TMAO) was recently identified as a promoter of
atherosclerosis. Patients with CKD exhibit accelerated development of atherosclerosis; …

The microbial metabolite trimethylamine N-oxide links vascular dysfunctions and the autoimmune disease rheumatoid arthritis

MM Chan, X Yang, H Wang, F Saaoud, Y Sun, D Fong - Nutrients, 2019 - mdpi.com
Diet and microbiota each have a direct impact on many chronic, inflammatory, and metabolic
diseases. As the field develops, a new perspective is emerging. The effects of diet may …

Intestinal Microbiota‐Generated Metabolite Trimethylamine‐N‐Oxide and 5‐Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal …

V Senthong, Z Wang, XS Li, Y Fan, Y Wu… - Journal of the …, 2016 - Am Heart Assoc
Background Trimethylamine‐N‐oxide (TMAO), a metabolite derived from gut microbes and
dietary phosphatidylcholine, is linked to both coronary artery disease pathogenesis and …

[HTML][HTML] Trimethylamine N-oxide (TMAO) is not associated with cardiometabolic phenotypes and inflammatory markers in children and adults

S Andraos, B Jones, K Lange, SA Clifford… - Current developments in …, 2021 - Elsevier
ABSTRACT Background Trimethylamine N-oxide (TMAO) is a diet-and microbiome-derived
metabolite and a proposed biomarker of adverse cardiometabolic outcomes. TMAO studies …