Genome-wide association studies (GWAS) have identified hundreds of loci associated with
kidney-related traits such as glomerular filtration rate, albuminuria, hypertension, electrolyte …

Genetic approaches have revolutionized our understanding of the fundamental causes of
human disease by permitting the identification of specific genes in which variation causes or …

Genome-wide association studies (GWASs) have advanced our understanding of the
genetic basis for common renal diseases, including chronic kidney disease (CKD) and …

A tight interplay of genetic predisposition and environmental factors define the onset and the
rate of progression of chronic renal disease. We are seeing a rapid expansion of information …

Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …

Advances in genome sequencing and genetic manipulation techniques over the last decade
have helped identify numerous single-gene causes of early-onset kidney diseases and risk …

Background Linking genetic risk loci identified by genome-wide association studies (GWAS)
to their causal genes remains a major challenge. Disease-associated genetic variants are …

Chronic kidney disease is common with up to 5% of the adult population reported to have an
estimated glomerular filtration rate of< 60 ml/min/1.73 m2. A large number of pathogenic …

The glomerulus consists of capillary tufts, a mesangial cell component and the Bowman
capsule. The glomerular filtration barrier is composed of glomerular endothelial cells, a …

Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to
10% of the US population. Genome-wide association studies (GWASs) have identified …