De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B.
Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) …

We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out
de novo methylation of the mouse genome during early postimplantation development and …

Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for
embryonic development in mammals. It has been shown that Dnmt3a and Dnmt3b have …

The DNTM3A and DNMT3B de novo DNA methyltransferases (DNMTs) are responsible for
setting genomic DNA methylation patterns, a key layer of epigenetic information. Here, using …

DNA methylation is an epigenetic modification associated with transcriptional repression of
promoters and is essential for mammalian development. Establishment of DNA methylation …

Inactive DNA methyltransferase (DNMT) 3B splice isoforms are associated with changes in
DNA methylation, yet the mechanisms by which they act remain largely unknown. Using …

Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for
maintenance of bulk DNA methylation and is essential for mouse development. However …

The genomic DNA is methylated by de novo methyltransferases Dnmt3a and Dnmt3b during
early embryonic development. The establishment of appropriate methylation patterns …

Several organisms have retained methyltransferase 2 (Dnmt2) as their only candidate DNA
methyltransferase gene. However, information about Dnmt2-dependent methylation patterns …

Abstract DNA methyltransferase 3a (DNMT3A) plays a crucial role during mammalian
development. Two isoforms of DNMT3A are differentially expressed from stem cells to …