Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
M Yagi, M Kabata, A Tanaka, T Ukai, S Ohta… - Nature …, 2020 - nature.com
De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B.
Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) …
Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) …
Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b
T Chen, Y Ueda, JE Dodge, Z Wang… - Molecular and cellular …, 2003 - Am Soc Microbiol
We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out
de novo methylation of the mouse genome during early postimplantation development and …
de novo methylation of the mouse genome during early postimplantation development and …
CpG sites preferentially methylated by Dnmt3a in vivo
M Oka, N Rodić, J Graddy, LJ Chang… - Journal of Biological …, 2006 - ASBMB
Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for
embryonic development in mammals. It has been shown that Dnmt3a and Dnmt3b have …
embryonic development in mammals. It has been shown that Dnmt3a and Dnmt3b have …
DNMT3L Modulates Significant and Distinct Flanking Sequence Preference for DNA Methylation by DNMT3A and DNMT3B In Vivo
BL Wienholz, MS Kareta, AH Moarefi, CA Gordon… - PLoS …, 2010 - journals.plos.org
The DNTM3A and DNMT3B de novo DNA methyltransferases (DNMTs) are responsible for
setting genomic DNA methylation patterns, a key layer of epigenetic information. Here, using …
setting genomic DNA methylation patterns, a key layer of epigenetic information. Here, using …
Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development
The genomic DNA is methylated by de novo methyltransferases Dnmt3a and Dnmt3b during
early embryonic development. The establishment of appropriate methylation patterns …
early embryonic development. The establishment of appropriate methylation patterns …
Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
T Baubec, DF Colombo, C Wirbelauer, J Schmidt… - Nature, 2015 - nature.com
DNA methylation is an epigenetic modification associated with transcriptional repression of
promoters and is essential for mammalian development. Establishment of DNA methylation …
promoters and is essential for mammalian development. Establishment of DNA methylation …
Inactive DNMT3B Splice Variants Modulate De Novo DNA Methylation
CA Gordon, SR Hartono, F Chédin - PloS one, 2013 - journals.plos.org
Inactive DNA methyltransferase (DNMT) 3B splice isoforms are associated with changes in
DNA methylation, yet the mechanisms by which they act remain largely unknown. Using …
DNA methylation, yet the mechanisms by which they act remain largely unknown. Using …
Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival
G Egger, S Jeong, SG Escobar… - Proceedings of the …, 2006 - National Acad Sciences
Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for
maintenance of bulk DNA methylation and is essential for mouse development. However …
maintenance of bulk DNA methylation and is essential for mouse development. However …
The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development
Abstract DNA methyltransferase 3a (DNMT3A) plays a crucial role during mammalian
development. Two isoforms of DNMT3A are differentially expressed from stem cells to …
development. Two isoforms of DNMT3A are differentially expressed from stem cells to …
Dnmt2-dependent methylomes lack defined DNA methylation patterns
G Raddatz, PM Guzzardo, N Olova… - Proceedings of the …, 2013 - National Acad Sciences
Several organisms have retained methyltransferase 2 (Dnmt2) as their only candidate DNA
methyltransferase gene. However, information about Dnmt2-dependent methylation patterns …
methyltransferase gene. However, information about Dnmt2-dependent methylation patterns …