Life expectancy rises steeply when a tumor is diagnosed at an early stage. Therefore,
diagnosing cancer before it turns into an aggressive, barely curable disease is one of the …

Epigenetic alterations are related to inherited but reversible changes in modifications that
regulate gene activity beyond the DNA sequence. DNA methylation is the best characterized …

In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an
important priority for assigning optimal treatment for each individual with suspected illness …

In recent years it has become apparent that epigenetic events are potentially equally
responsible for cancer initiation and progression as genetic abnormalities. DNA methylation …

Epigenetics, transcending genetics, genomics, and molecular biology, is now poised to be
the avant-garde beacon of biological science. The rise of DNA methylation studies marks a …

Aberrant DNA methylation is ubiquitous in human cancer and has been shown to occur
early during carcinogenesis, thus providing attractive potential biomarkers for the early …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

The increase in recent scientific studies on cancer biomarkers has brought great new
insights into the field. Moreover, novel technological breakthroughs such as long read …

Cancer contributes to a large proportion of the mortality and morbidity in the United States
and worldwide. Despite advances in diagnosis and treatment of various cancers, early …