Mammalian development is associated with considerable changes in global DNA
methylation levels at times of genomic reprogramming. Normal DNA methylation is essential …

Parent-specific differentially methylated regions (DMRs) are established during
gametogenesis and regulate parent-specific expression of imprinted genes. Monoallelic …

There is a significant amount of variation in DNA methylation characteristics across
organisms. Likewise, the biological role of DNA methylation varies across taxonomic …

DNA methylation predominantly occurs at CG dinucleotides in vertebrate genomes;
however, non-CG methylation (mCH) is also detectable in vertebrate tissues, most notably in …

Major evolutionary transitions are enigmas, and the most notable enigma is between
invertebrates and vertebrates, with numerous spectacular innovations. To search for the …

The germline is the only cellular lineage capable of transferring genetic information from one
generation to the next. Intergenerational transmission of epigenetic memory through the …

While DNA cytosine methylation is relatively stable in somatic tissues, it is highly dynamic
during preimplantation development. A recent study in Nature by Meissner and colleagues …

Background DNA methylation is an epigenetic mechanism with important regulatory
functions in animals. While the mechanism itself is evolutionarily ancient, the distribution and …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …