DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

Methylation of CpG dinucleotides is a predominant modification of genomic DNA in many
species, especially in vertebrates. This modification, generally associated with …

DNA methylation plays important roles during development. However, the DNA methylation
reprogramming of functional elements has not been fully investigated during mammalian …

Gene expression is under the influence of DNA methylation and assembly of chromatin
structure. This paper reports the modulation of transgene expression in zebrafish embryos …

Age-related changes in DNA methylation have been demonstrated in mammals, but it
remains unclear as to the generality of this phenomenon in vertebrates, which is a criterion …

Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …

Cytosine methylation is a com-mon DNA modification found in most eukaryotic organisms
including plants, animals, and fungi (1, 2). The addition of a methyl group to cytosine …

From a fertilised egg to a mature organism, cells divide and accumulate epigenetic
information, which is faithfully passed on to daughter cells. DNA methylation consolidates …

Marked epigenetic reprogramming is essential to convert terminally differentiated gametes
to totipotent embryos. It remains puzzling why postfertilization global DNA reprogramming …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …