Deafness commonly results from a lesion of the sensory cells and/or of the neurons of the
auditory part of the inner ear. There are currently no treatments designed to halt or reverse …

The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory
cells required for hearing and balance. Recent studies in both lower vertebrates and …

Much has been accomplished since the discovery of postembryonic hair cell production and
hair cell regeneration in nonmammals decades ago. No therapies for hair cell regeneration …

Hair cell loss in higher vertebrates appears to be permanent. Progenitors that are quiescent
in the organ of Corti are the best candidates for the restoration of the different cell types in …

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair
cells are lost following an injury, no recovery could occur. However, during the first postnatal …

The vertebrate inner ear is derived from the otic placode and undergoes a complicated
series of morphogenetic processes to differentiate into an elaborate structure harboring …

The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …

Loss of sensory hair cells is the leading cause of deafness in humans. The mammalian
cochlea cannot regenerate its complement of sensory hair cells. Thus at present, the only …

Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …

The discovery of avian cochlear hair cell regeneration in the late 1980s and the concurrent
development of new techniques in molecular and developmental biology generated a …