Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …

Epigenetic dysregulation of gene expression is thought to be critically involved in the
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …

Gene expression is modulated by epigenetic factors that come in varying forms, such as
DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent …

Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Epigenetic modulations play essential roles in diverse biological processes. During the past
several years, DNA demethylation has been discovered in embryonic and postnatal …

Abstract The formation of 5-hydroxymethylcytosine (5hmC), a key intermediate of DNA
demethylation, is driven by the ten eleven translocation (TET) family of proteins that oxidize …

Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …

DNA methylation primarily occurs within human cells as a 5-methylcytosine (5mC)
modification of the cytosine bases in CpG dinucleotides. 5mC has proven to be an important …

The observation that Alzheimer's disease (AD) patients with similar and even identical
genetic backgrounds often present with heterogeneous pathologies has prompted the …

We collected blood DNA from 120 late-onset Alzheimer's disease (AD) patients and 115
healthy matched controls and analysed the methylation levels of genes involved in amyloid …