The rapid advances in high‐throughput sequencing technologies have made it more evident
that epigenetic modifications orchestrate a plethora of complex biological processes. During …

The study of DNA methylation has been a rapidly expanding field since its dawn in the
1960s. DNA methylation is an epigenetic modification that plays a crucial role in guiding the …

Epigenome regulation is a critical mechanism that governs cell identity, lineage specification
and developmental cell fates. With the advent of low-input and single-cell technologies as …

Aberrant DNA methylation is a characteristic feature of cancers including blood
malignancies. Mutations in the DNA methylation regulators DNMT3A, TET1/2, and IDH1/2 …

The term epigenetics defines a heritable alteration in gene expression without an
accompanying change in primary DNA sequence. Two major mechanisms that foster …

DNA methylation is a well-studied epigenetic modification essential for efficient cellular
differentiation. Aberrant DNA methylation patterns are a characteristic feature of cancer …

Cancer is also an epigenetic disease. The main epigenetic modification in humans is DNA
methylation. Transformed cells undergo a dramatic change in their DNA methylation …

DNA methylation represents a crucial mechanism of epigenetic regulation in hematologic
malignancies. The methylation process is controlled by specific DNA methyl transferases …

DNA methylation provides a major epigenetic code (besides histone modification) of the
lineage-and developmentspecific genes (such as regulators of differentiation in the …

Genetic alterations, including DNA sequence and copy number alterations, have been
characterized in human cancers for over several decades. However, it is becoming …